VAV1

VAV1, Vav guanine nucleotide exchange factor 1, alias VAV, is a signaling protein and a member of the Vav family. VAV1 is mainly expressed in hematopoietic cells, including T cells, B cells, monocytes, natural killer (NK) cells, granulocytes, and dendritic cells.
The mechanism of action of VAV1 involves the activation of signaling pathways leading to actin cytoskeleton rearrangement and transcriptional alterations as a phosphorylation-dependent GDP/GTP exchange factor (GEF) of the Rho subfamily of GTPases.
VAV1 plays an important role in the development and activation of T and B cells and is involved in the regulation of immune cell growth, proliferation, transformation and migration. VAV1 has an important effect on the intensity of response to T cell receptor activation, especially events such as activation of transcription factors involving calcium ions.
Aberrant expression of VAV1 is associated with a variety of diseases, including autoimmune disorders and tumor progression, making it a potential target for therapeutic and interventional cancer treatment.