SYK

SYK, spleen tyrosine kinase, alias KSYK, p72syk.SYK is encoded by the human SYK gene, which is widely expressed in hematopoietic cells and is involved in coupling activated immune receptors to downstream signaling events that mediate a wide range of cellular responses, including proliferation, differentiation, and phagocytosis.
The mechanism of action of SYK involves its central role in B-cell receptor (BCR) responses as a member of the non-receptor Tyr protein kinase family, acting as an upstream activator of pathways such as PI3K, PLCgamma2, and Rac/cdc42. SYK plays a critical role in adaptive immune receptor signaling, and recent studies have demonstrated that SYK also mediates other diverse biological functions, including cell adhesion, innate immune recognition, osteoclast maturation, platelet activation, and vascular development. SYK also plays a critical role in autoimmune diseases and hematologic malignancies.