RHD

RHD, also known as the RhD antigen, is a crucial antigen present on the surface of red blood cells in the Rh blood group system. It is primarily composed of transmembrane and extracellular domains, whose structural characteristics enable RHD antigen to participate in blood type identification and immune response. The Fc fragment of the RHD antigen binds to the Fc receptor on the surface of immune cells, thereby initiating a series of signaling pathways that are involved in the regulation and effects of immune responses. Although RHD antigen primarily serves as a blood type marker, its strength and distribution may be associated with the occurrence and progression of certain diseases. Understanding the structure and function of RHD antigen can help us better comprehend the mechanisms of the blood group system and related diseases.