PLIN2

PLIN2, or lipoprotein 2, alias ADFP, ADRP, etc. PLIN2 is associated with lipid globule surface membrane substances and may be involved in the development and maintenance of adipose tissue. PLIN2 is not only present in adipocytes, but has also been found in a wide variety of cultured cell lines and tissues including fibroblasts, endothelial cells, epithelial cells, as well as in lactating mammary glands, adrenal cortical, Sertoli and Leydig cells, and hepatocytes in alcoholic cirrhosis, suggesting that it can serve as a marker for lipid accumulation in a variety of cell types and diseases.
PLIN2 expression and activity are regulated by multiple factors, such as oxidized low-density lipoprotein (ox-LDL), docosahexaenoic acid (DHA), and autophagy that can affect PLIN2 and triglyceride (TG) levels. The specific regulatory role of PLIN2 in lipid metabolism is important for addressing early atherosclerotic pathologies caused by lipid accumulation.