PDE5A

PDE5A, or phosphodiesterase 5A, is a member of the phosphodiesterase family with primary functions in the cardiovascular and central nervous systems. It regulates intracellular signal transduction by hydrolyzing cGMP and cAMP, thereby affecting vascular relaxation, platelet function, and neurotransmitter release. PDE5A's activity is associated with conditions such as cardiovascular disease, sexual dysfunction, and certain cancers. Inhibitors of PDE5A, like sildenafil, are used to treat erectile dysfunction and pulmonary hypertension and may also contribute to neuroprotection and anticancer therapies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDE5A Antibody(CSB-PA126186)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA126186(PDE5A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

The following PDE5A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PDE5A Antibodies

PDE5A Proteins

PDE5A Antibodies

PDE5A Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA126186	PDE5A Antibody	Human	ELISA,WB,IHC
CSB-PA132496	PDE5A Antibody	Human	ELISA,IHC

PDE5A Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA807017ZA01MO	Pde5a Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

PDE5A Proteins

PDE5A Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP529249DO CSB-EP529249DO CSB-BP529249DO CSB-MP529249DO CSB-EP529249DO-B	Recombinant Dog cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDE5A Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP524921HU CSB-EP524921HU CSB-BP524921HU CSB-MP524921HU CSB-EP524921HU-B	Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP524921HU	Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) , partial	Yeast

PDE5A Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP523851RA CSB-EP523851RA CSB-BP523851RA CSB-MP523851RA CSB-EP523851RA-B	Recombinant Rat cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDE5A Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP634661BO CSB-EP634661BO CSB-BP634661BO CSB-MP634661BO CSB-EP634661BO-B	Recombinant Bovine cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PDE5A Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP807017MO CSB-EP807017MO CSB-BP807017MO CSB-MP807017MO CSB-EP807017MO-B	Recombinant Mouse cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP807017MO	Recombinant Mouse cGMP-specific 3,5-cyclic phosphodiesterase (Pde5a), partial	E.coli

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PDE5A

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