NOD1

NOD1, nucleotide-binding oligomerization domain-containing 1, alias CARD4, NLRC1, CLR7.1, etc. It is a protein expressed in human cells and belongs to the nucleotide-binding oligomerization structural domain (NOD)-like receptor (NLR) family.
The mechanism of action of NOD1 is to recognize bacterial peptidoglycan through its N-terminal caspase-recruiting structural domain (CARD), centrally located nucleotide-binding domain (NBD), and C-terminal 10 tandemly linked leucine-rich repeats (LRRs). NOD1 is also involved in immune responses to viral and parasitic infections. NOD1 recognizes pathogenic microorganisms and activates downstream inflammatory and immune responses through the function of pattern recognition receptors (PRRs).
Mutations in NOD1 have been associated with a wide range of disorders including asthma, inflammatory bowel disease, leukodystrophies, and tuberculosis.