MDM2

MDM2, or murine double microsomal gene 2 protein, alias E3 ubiquitin-protein ligase MDM2, P53-binding protein. It is an E3 ubiquitin ligase encoded by the MDM2 gene, which is mainly expressed in the nucleoplasm and is associated with the ubiquitination degradation pathway of a variety of proteins.One of the mechanisms of action of MDM2 is to mediate the ubiquitination of p53/TP53, leading to its degradation by the proteasome.In addition, MDM2 is involved in the process of apoptosis, inhibiting p53/TP53 and p73/TP73-mediated cell cycle arrest and apoptosis by binding to its transcriptional activation domain. /TP73-mediated cell cycle arrest and apoptosis.

MDM2 has a wide range of biological significance, which is not only involved in the regulation of p53 stability and biological functions, but also in a variety of cell physiological processes such as the cell cycle, apoptosis, and the response to DNA damage.The interactions between MDM2 and p53 form an autoregulatory negative feedback loop, which is essential for maintaining the stability of the intracellular environment . In addition, MDM2 controls T cell-mediated anti-tumor immunity by regulating STAT5 stability, which provides a new perspective and potential target for cancer immunotherapy .