LY96

LY96, Lymphocyte Antigen 96, also known as MD-2, ESOP-1, Ly-96, etc. LY96 plays an important role in natural immunity and is the body's first line of defense against microbial infections.
Studies have shown that LY96 may be involved in endotoxin neutralization and plays a role in inflammation-related and immune-related diseases, such as Crohn's disease, rheumatoid arthritis and diabetic cardiomyopathy. In addition, LY96 is closely associated with tumorigenesis and progression, and it promotes colon cancer cell proliferation and lung metastasis by interacting with TLR4 to activate the nuclear factor-κB (NF-κB) pathway. In Parkinson's disease (PD), the expression of LY96 was abnormally elevated, which may be involved in PD through the natural killer cell-mediated cytotoxicity pathway and the extracellular matrix receptor interaction pathway. These findings suggest that LY96 not only plays a role in infection and immune response, but may also be a potential biomarker and therapeutic target for a variety of diseases, including Parkinson's disease.