KMT5A

KMT5A, also known as SETD8, is the protein encoded by this gene. It's also commonly referred to as PR-SET7 or SET8. KMT5A is a lysine methyltransferase that specifically monomethylates histone H4 at lysine 20 (H4K20me1), playing crucial roles in DNA replication, cell cycle regulation, and chromatin organization. This protein is involved in the p53 signaling pathway.
Aberrant expression of KMT5A has been linked to various diseases, particularly cancers like breast and colon cancer. Currently, there is ongoing research to develop drugs targeting KMT5A. Inhibitors of this protein are being explored as potential anti - cancer therapies due to its key functions in tumorigenesis.

Popular Product:

KMT5A Antibody(CSB-PA889082LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA889082LA01HU at dilution of 1:100

The following KMT5A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KMT5A Antibodies

KMT5A Proteins

KMT5A Antibodies

KMT5A Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA889082LA01HU	KMT5A Antibody	Human	ELISA, IHC
CSB-PA889082LC01HU	KMT5A Antibody, FITC conjugated	Human

KMT5A Proteins

KMT5A Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP889082HU CSB-EP889082HU CSB-BP889082HU CSB-MP889082HU CSB-EP889082HU-B	Recombinant Human N-lysine methyltransferase SETD8 (SETD8)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KMT5A Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP648990BO CSB-EP648990BO CSB-BP648990BO CSB-MP648990BO CSB-EP648990BO-B	Recombinant Bovine N-lysine methyltransferase SETD8 (SETD8)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KMT5A Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Code	Product Name	Source
CSB-YP611723XBF CSB-EP611723XBF CSB-BP611723XBF CSB-MP611723XBF CSB-EP611723XBF-B	Recombinant Xenopus tropicalis N-lysine methyltransferase SETD8 (setd8)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KMT5A Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP651334MO CSB-EP651334MO CSB-BP651334MO CSB-MP651334MO CSB-EP651334MO-B	Recombinant Mouse N-lysine methyltransferase SETD8 (Setd8)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

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Hippo signaling pathway

TGF-beta signaling pathway

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