KAT2A

KAT2A, or lysine acetyltransferase 2A, is also known as GCN5, hGCN5, GCN5L2, and PCAF-b. It is a histone acetyltransferase (HAT) that is widely expressed in human cells, and its main role is to act as a transcriptional activator to promote transcriptional activation of genes through acetylation of histones.
KAT2A also has other functions, such as acting as a deterrent for NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA. In addition, KAT2A is involved in a variety of biological processes, including long-term memory, positive regulation of macromolecular metabolic processes, and regulatory T-cell differentiation, etc.
Abnormal expression of KAT2A has been associated with a variety of diseases, such as cancer and metabolic disorders, and is one of the most important targets for drug development.

Popular Product:

KAT2A Antibody(CSB-PA002657)

Validated Data

IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-PA002657 diluted at 1:66 and staining in paraffin-embedded human melanoma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of Hela cell with CSB-PA002657 at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following KAT2A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KAT2A Antibodies

KAT2A Proteins

KAT2A Antibodies

KAT2A Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA011987GA01HU	KAT2A Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA002657	KAT2A Antibody	Human	IF, IHC, ELISA
CSB-PA821706LA01HU	KAT2A Antibody	Human	ELISA, IHC
CSB-PA821706LD01HU	KAT2A Antibody, Biotin conjugated	Human	ELISA

KAT2A Proteins

KAT2A Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP821706HU CSB-EP821706HU CSB-BP821706HU CSB-MP821706HU CSB-EP821706HU-B	Recombinant Human Histone acetyltransferase KAT2A (KAT2A), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

KAT2A Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP884898MO CSB-EP884898MO CSB-BP884898MO CSB-MP884898MO CSB-EP884898MO-B	Recombinant Mouse Histone acetyltransferase KAT2A (Kat2a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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