IGHE

IGHE encodes the immunoglobulin heavy constant epsilon protein, also commonly known as IgE heavy chain. This protein is a key component of immunoglobulin E (IgE), an antibody class involved in the immune response. IgE binds to allergens, triggering the release of histamine from mast cells and basophils through the FcεRI signaling pathway. It plays a crucial role in allergic reactions and defense against parasites.
Dysregulation of IgE is associated with various allergic diseases, such as allergic rhinitis and asthma. In drug development, monoclonal antibodies targeting IgE, like omalizumab, have been approved. They work by binding to free IgE, reducing its interaction with receptors and thus alleviating allergic symptoms. Ongoing research aims to develop more effective and targeted therapies.