IFNAR2

IFNAR2, also known as Interferon Alpha and Beta Receptor Subunit 2, is a key component of the type I interferon receptor complex. It has no widely - known common aliases. This protein plays a crucial role in the immune response by binding to type I interferons. Once bound, it activates downstream signaling cascades such as the JAK - STAT pathway, which leads to the transcription of interferon - stimulated genes.
Genetic mutations or dysregulation of IFNAR2 are associated with autoimmune diseases and certain types of cancers. In drug development, targeting IFNAR2 has emerged as a potential strategy. Some monoclonal antibodies are in pre - clinical or early - stage clinical trials aiming to modulate its activity for therapeutic benefits.