IAPP

IAPP, also known as islet amyloid polypeptide, is a 37-amino acid polypeptide secreted by pancreatic beta cells, which plays a key role in maintaining blood glucose balance and regulating glucose homeostasis. As an amphipathic polypeptide, the structural characteristics of IAPP make it have certain biological activity under physiological and pathological conditions. In recent years, studies have found that IAPP not only plays a role in the pancreas, but also expresses in human brain tissue, which is closely related to cognitive decline and the occurrence of Alzheimer's disease AD. Although the signaling pathways directly involved in IAPP are not fully understood, it can be speculated that it may indirectly affect signaling pathways related to glucose metabolism, pancreatic function, and inflammatory response. Therefore, the potential role of IAPP in diabetes and neurodegenerative diseases requires further research and exploration.