HSP90AB1, heat shock protein HSP 90-beta, alias HSP84, HSPC2, HSPCB, D6S182, HSP90B, etc. HSP90AB1 is encoded by the human HSP90AB1 gene, which is located on chromosome 6 in the p21.1 region. HSP90AB1 is a molecular chaperone protein that belongs to the heat shock protein 90 family and is involved in signal transduction, protein folding and degradation, and morphological evolution.
HSP90AB1 interacts with a variety of proteins in the cell and affects several biological processes, including the maturation of the peptide-loaded MHC1 complex in spermatocytes, the processing of hERG ion channels during their maturation, as well as the biogenesis of the KCNQ4 channel and the endothelial nitric oxide synthase (eNOS) activity regulation.
In addition, HSP90AB1 is involved in the release of secretory exosomes that promote wound healing and inflammatory responses. In cancer, these functions can be utilized by cancer cells, thereby promoting their invasion and metastasis. High expression of HSP90AB1 is significantly associated with poor prognosis in several cancer types, making it an important target for cancer therapy.
Popular
Product:
Recombinant Human Heat shock protein HSP 90-beta (HSP90AB1)(CSB-EP010808HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010808HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90AB1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010808HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HSP90AB1.
HSP90AB1 Recombinant Monoclonal Antibody(CSB-RA644510A0HU)
Validated Data
IHC image of CSB-RA644510A0HU diluted at 1:50 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.74% DAB.
IHC image of CSB-RA644510A0HU diluted at 1:50 and staining in paraffin-embedded human rectal cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.74% DAB.
Overlay Peak curve showing Hela cells stained with CSB-RA644510A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
The following HSP90AB1
reagents supplied by CUSABIO are manufactured under a
strict quality control system. Multiple applications
have been validated and solid technical support is
offered.
HSP90AB1 Proteins
HSP90AB1 Proteins for Equus caballus (Horse)
HSP90AB1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
HSP90AB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
HSP90AB1 Proteins for Rattus norvegicus (Rat)
HSP90AB1 Proteins for Homo sapiens (Human)
HSP90AB1 Proteins for Oryctolagus cuniculus (Rabbit)
HSP90AB1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
HSP90AB1 Proteins for Bos taurus (Bovine)
HSP90AB1 Proteins for Mus musculus (Mouse)
