GSK3B

GSK3B encodes glycogen synthase kinase 3 beta, also known as GSK - 3β. It is a serine/threonine protein kinase with well - known aliases like tau protein kinase I. The protein regulates glycogen synthesis by phosphorylating and inactivating glycogen synthase. It is also involved in various cellular processes such as cell cycle regulation and apoptosis through the Wnt/β - catenin signaling pathway.
GSK3B has been linked to several diseases, including Alzheimer's disease, diabetes, and some cancers. In drug development, many small - molecule inhibitors targeting GSK3B are under research. These inhibitors aim to correct the dysregulated signaling associated with the aforementioned diseases, offering potential therapeutic strategies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GSK3B Recombinant Monoclonal Antibody(CSB-RA216259A0HU)

Validated Data

Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate, 293 whole cell lysate
All lanes: GSK3 beta Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 47, 49 kDa
Observed band size: 47 kDa

IHC image of CSB-RA216259A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of Hela Cells with CSB-RA216259A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

The following GSK3B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GSK3B Antibodies

GSK3B Proteins

GSK3B Antibodies

GSK3B Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA009963GA01HU	GSK3B Antibody	Human,Mouse,Rat,Pig	ELISA,WB
CSB-PA120951	GSK3B (Ab-9) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA166926	Phospho-GSK3B (Ser9) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA575559	Phospho-GSK3A/GSK3B (Tyr279/216) Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA255909	GSK3A/GSK3B (Ab-279/216) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA939628	GSK3B Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA000535	Phospho-GSK3A/GSK3B (Y279/216) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA000536	Phospho-GSK3B (S9) Antibody	Human,Mouse,Rat	WB, IHC, IP, ELISA
CSB-PA000636	Phospho-GSK3B (S9) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA002838	GSK3A/GSK3B Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA002848	GSK3B Antibody	Human,Mouse,Rat	WB, IHC, IP, ELISA
CSB-PA009038	GSK3B Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA080166	GSK3B Antibody	Mouse,Rat	WB, IHC
CSB-PA009963LA01HU	GSK3B Antibody	Human, Mouse	ELISA, WB, IF
CSB-PA009963LB01HU	GSK3B Antibody, HRP conjugated	Human	ELISA
CSB-RA009963A09phHU	Phospho-GSK3B (Ser9) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF
CSB-RA216259A0HU	GSK3B Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF

GSK3B Proteins

GSK3B Proteins for Spermophilus citellus (European suslik) (Citellus citellus)

Code	Product Name	Source
CSB-YP723085SJE CSB-EP723085SJE CSB-BP723085SJE CSB-MP723085SJE CSB-EP723085SJE-B	Recombinant Spermophilus citellus Glycogen synthase kinase-3 beta (GSK3B)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GSK3B Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP009963HU	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)	Yeast
CSB-EP009963HU	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)	E.coli
CSB-YP009963HU CSB-EP009963HU CSB-BP009963HU CSB-MP009963HU CSB-EP009963HU-B	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP009963HUe2	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)	E.coli
CSB-EP009963HU(M2)c7	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)(Y134P)	E.coli
CSB-EP009963HU(M3)c7	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)(D200P)	E.coli
CSB-EP009963HUc7	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)	E.coli
CSB-EP009963HU(M1)c7	Recombinant Human Glycogen synthase kinase-3 beta (GSK3B)(K85P)	E.coli

GSK3B Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP009963RA CSB-EP009963RA CSB-BP009963RA CSB-MP009963RA CSB-EP009963RA-B	Recombinant Rat Glycogen synthase kinase-3 beta (Gsk3b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GSK3B Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP892998MO CSB-EP892998MO CSB-BP892998MO CSB-MP892998MO CSB-EP892998MO-B	Recombinant Mouse Glycogen synthase kinase-3 beta (Gsk3b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GSK3B Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP856250XBE CSB-EP856250XBE CSB-BP856250XBE CSB-MP856250XBE CSB-EP856250XBE-B	Recombinant Xenopus laevis Glycogen synthase kinase-3 beta (gsk3b)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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GSK3B

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