FZD8

Frizzled-8 (FZD8) is a key protein within the Frizzled family. It is also commonly known as hFz8. Functionally, FZD8 plays a crucial role in the Wnt signaling pathway. By binding to Wnt ligands, it activates downstream cascade reactions, thereby regulating cell proliferation, differentiation, and migration.
Alterations in FZD8 are associated with multiple diseases, particularly cancers such as colorectal cancer and gastric cancer. Due to its significant role, FZD8 has become an attractive target in drug research. Currently, researchers are exploring inhibitors that can block its interaction with Wnt ligands to halt abnormal cell growth.