CASR

CASR, or calcium-sensing receptor, is a C-family GPCR (G protein-coupled receptor) predominantly found in the thyroid, parathyroid, bone, intestinal system, and kidney. It plays a pivotal role in regulating calcium ion balance in the body by sensing changes in calcium ion concentration. Mutations in CASR can lead to hypercalcemia or hypocalcemia, and it also senses a variety of endogenous substances, such as amino acids and polypeptides. CASR is crucial for maintaining calcium balance and bone metabolism, making it an important drug target.