BACE1

BACE1, known in full as β-secretase 1, is a chromosome 11-derived aspartic protease. It is noted for its role in generating Aβ peptides by cleaving amyloid precursor protein (APP), a critical step in Alzheimer's disease (AD) development. BACE1's influence also extends to cardiovascular and metabolic diseases like diabetes and atherosclerosis. As a significant biological target, BACE1 inhibitors are in development for AD treatment and have shown promise for metabolic disease intervention. While the full scope of BACE1's biological impact is under investigation, it has become a focal point in neuroscience and drug development.

Validated Data

Western Blot
Positive WB detected in: MCF-7 whole cell lysate, Rat brain tissue, Mouse brain tissue
All lanes: BACE1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 53, 52, 49, 46, 43 kDa
Observed band size: 72 kDa

Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit(CSB-E09824h)

Validated Data

Code: CSB-E09824h

Size: 96T,5×96T,10×96T

Sensitivity: 0.78 pg/mL

Detection Range: 3.12 pg/mL-200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following BACE1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BACE1 Antibodies

BACE1 Proteins

BACE1 ELISA Kits

BACE1 Antibodies

BACE1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA002524GA01HU	BACE1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA008418	BACE1 Antibody	Human,Mouse,Rat	IHC, IF, ELISA
CSB-PA173556	BACE1 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA150463	BACE1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA002524LA01HU	BACE1 Antibody	Human	ELISA, IHC, IF
CSB-PA002524LB01HU	BACE1 Antibody, HRP conjugated	Human	ELISA
CSB-PA002524LC01HU	BACE1 Antibody, FITC conjugated	Human
CSB-PA002524LD01HU	BACE1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA177574A0HU	BACE1 Recombinant Monoclonal Antibody	Human, Mouse, Rat	ELISA, WB

BACE1 Proteins

BACE1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF002524RA	Recombinant Rat Beta-secretase 1 (Bace1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP002524RA1 CSB-EP002524RA1 CSB-BP002524RA1 CSB-MP002524RA1 CSB-EP002524RA1-B	Recombinant Rat Beta-secretase 1 (Bace1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BACE1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF002524HU	Recombinant Human Beta-secretase 1 (BACE1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP002524HU1 CSB-EP002524HU1 CSB-BP002524HU1 CSB-MP002524HU1 CSB-EP002524HU1-B	Recombinant Human Beta-secretase 1 (BACE1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BACE1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP642235BO CSB-EP642235BO CSB-BP642235BO CSB-MP642235BO CSB-EP642235BO-B	Recombinant Bovine Beta-secretase 1 (BACE1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BACE1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF002524MO	Recombinant Mouse Beta-secretase 1 (Bace1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP002524MO1 CSB-EP002524MO1 CSB-BP002524MO1 CSB-MP002524MO1 CSB-EP002524MO1-B	Recombinant Mouse Beta-secretase 1 (Bace1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BACE1 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP629703GU CSB-EP629703GU CSB-BP629703GU CSB-MP629703GU CSB-EP629703GU-B	Recombinant Guinea pig Beta-secretase 1 (BACE1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BACE1 ELISA Kit

BACE1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E09824h	Human β-site APP-Cleaving Enzyme 1,BACE1 ELISA kit	serum, plasma, tissue homogenates	0.78 pg/mL

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BACE1

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