ATM

ATM, a serine/threonine protein kinase within the PI3K-like protein kinase (PIKKs) family, is central to DNA damage response. Predominantly nuclear, ATM's gene resides on chromosome 11. It springs into action at DNA double strand breaks, phosphorylating proteins like p53 and Chk2, which triggers cell cycle arrest, DNA repair, and apoptosis. ATM is vital for genomic stability and countering cancer, as well as for reactions to radiation and chemotherapeutic agents. The disorder of ATM can result in Ataxia telangiectasia, marked by neurological issues, cancer predisposition, and immune system impairments.

Validated Data

IHC image of CSB-RA166706A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA166706A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Overlay histogram showing Hela cells stained with CSB-RA166706A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then incubated in 10% normal goat serum to block non-specific protein-protein interactions followedby the antibody (1µg/1*10⁶ cells) for 1 h at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1µg/1*10⁶ cells) used under the same conditions. Acquisition of >10,000 events was performed.

The following ATM reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ATM Antibodies

ATM Proteins

ATM Antibodies

ATM Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA188639	Phospho-ATM (Ser1981) Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA272996	ATM (Ab-1981) Antibody	Human,Mouse	ELISA,WB,IF
CSB-PA020042	ATM Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA020043	ATM Antibody	Human	IHC, ELISA
CSB-PA465029	Phospho-ATM (Ser1981) Antibody	Human,Mouse	WB, ELISA
CSB-PA612595	ATM Antibody	Human,Mouse,Rat	IHC,ELISA
CSB-PA243808	ATM Antibody	Human,Mouse,Rat	IHC,ELISA
CSB-RA618770A1981phHU	Phospho-ATM (S1981) Recombinant Monoclonal Antibody	Human	ELISA, IF
CSB-RA618770A0HU	ATM Recombinant Monoclonal Antibody	Human	ELISA, WB, IP
CSB-RA166706A0HU	ATM Recombinant Monoclonal Antibody	Human	ELISA, IHC, FC

ATM Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA885532XA01DOA	ATM Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

ATM Proteins

ATM Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP618770HU CSB-EP618770HU CSB-BP618770HU CSB-MP618770HU CSB-EP618770HU-B	Recombinant Human Serine-protein kinase ATM (ATM), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATM Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP885532DOA CSB-EP885532DOA CSB-BP885532DOA CSB-MP885532DOA CSB-EP885532DOA-B	Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATM (ATM), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATM Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP754283PI CSB-EP754283PI CSB-BP754283PI CSB-MP754283PI CSB-EP754283PI-B	Recombinant Pig Serine-protein kinase ATM (ATM), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ATM Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP726793MO CSB-EP726793MO CSB-BP726793MO CSB-MP726793MO CSB-EP726793MO-B	Recombinant Mouse Serine-protein kinase ATM (Atm), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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ATM

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