IL12RB1 Recombinant Monoclonal Antibody

IL12RB1, also known as CD212, serves as an essential component of the interleukin-12 receptor complex that plays a central role in bridging innate and adaptive immunity. This receptor subunit is critical for IL-12 and IL-23 signaling pathways, which drive Th1 cell differentiation and IFN-γ production—processes fundamental to host defense against intracellular pathogens and tumor surveillance. Deficiencies in IL12RB1 are associated with primary immunodeficiency disorders, making this target particularly relevant for researchers investigating immune dysregulation, infectious disease susceptibility, and immunotherapy development.

This recombinant monoclonal antibody, clone 7C11, offers the reproducibility and consistency that demanding immunological research requires. Produced using recombinant technology with a defined sequence, this antibody eliminates the lot-to-lot variability inherent in traditional hybridoma-derived reagents, ensuring your experimental results remain comparable across extended studies. The human IgG1 isotype format and affinity-chromatography purification deliver a high-purity reagent suitable for sensitive detection applications.

Validation data demonstrates robust binding activity against human IL12RB1, with functional ELISA testing showing an EC50 range of 1.578–2.143 ng/mL when detecting immobilized human IL12RB1 protein at 2 μg/mL. This high-affinity binding supports reliable quantitative measurements at working dilutions between 1:5,000 and 1:50,000, providing flexibility to optimize signal-to-background ratios for your specific experimental conditions.

Supplied in a glycerol-based PBS buffer for long-term stability at -20°C or -80°C, this antibody is well-suited for immunology researchers exploring IL-12/IL-23 signaling dynamics, immune checkpoint mechanisms, or biomarker development in inflammatory and infectious disease contexts.