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Recombinant Drosophila melanogaster Protein son of sevenless (Sos), partial

Recombinant Drosophila melanogaster Protein son of sevenless (Sos), partial

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Sos

Uniprot NO.

P26675

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-1596

Target Protein Sequence

MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA GLQDCDGYDF TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK LCLRLLAMLC AKPLPHSVQD VEEKVNKSFP APIDQWALNE AKEVINSKKR KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL VAVLEYISAD ILKMAGDYVI KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL PAQRASATYE ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ ASRDALNNLL SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY IKHLKDLSSS QDDIESFEQV QGLLHPLHCD LEKVMASLSK ERQVPVSGRV RRQLAIERTR ELQMKVEHWE DKDVGQNCNE FIREDSLSKL GSGKRIWSER KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR VDINDRPDSD DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI ERLTYHIYAD PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT GTAGAGGMGG VGGDKEHKNS HREDWKRYRK EYVQPVQFRV LNVLRHWVDH HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW VDSVLKIVQR KNEQEKSNKK IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL EFEMYKNVKP SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL EECRELSDDH LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT ELINFSKRRK VAEIIGEIQQ YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK QMSDYLYNES LRIEPRGCKT VPKFPRKWPH IPLKSPGIKP RRQNQTNSSS KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT AAAANAGSGT LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS DTEAPPSPLP KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS GGEEFCAGGF YFNSAHQGQP GAVPISPHVN VPMATNMEYR AVPPPLPPRR KERTESCADM AQKRQAPDAP TLPPRDGELS PPPIPPRLNH STGISYLRQS HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN QAAAGPISTT LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS SPKEFFPIAT SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.

Gene References into Functions

data support a model in which Robo's ligand-dependent internalization from cell surface to late endosome is essential for receptor activation and proper repulsive guidance at the midline by allowing recruitment of the downstream effector Son of Sevenless PMID:26335920
identifies DRK/DOS/SOS as the upstream Rac GEF complex required for glial responses to axonal injury, and demonstrates a critical requirement for multiple GEFs in efficient glial activation after injury and internalization/degradation of axonal debris PMID:25099352
Signalling from the pTyr (YB) Neu (ErbB-2) autophosphorylation site was affected by a haplosufficiency in drk (Grb-2), and in genes thought to function downstream of Grb-2: dab, sos, csw (Shp-2), and dos (Gab-1). PMID:12673197
SosM98, an allele with a single amino acid substitution in the RacGEF motif, functions as a dominant negative in vivo to downregulate receptor tyrosine kinase signaling. PMID:15286999
These results provide in vivo evidence that the Ras and RhoGEF domains of Sos are separable signaling modules and support a model in which Robo recruits Sos to the membrane via Dock to activate Rac during midline repulsion. PMID:17114045