SLC27A2 Antibody

Code: CSB-PA021534LA01HU

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

O14975

Target Names

SLC27A2

Alternative Names

ACSVL1 antibody; FACVL1 antibody; FATP 2 antibody; FATP-2 antibody; FATP2 antibody; Fatty acid coenzyme A ligase, very long chain 1 antibody; Fatty acid transport protein 2 antibody; Fatty-acid-coenzyme A ligase antibody; hFACVL1 antibody; HsT17226 antibody; Long chain fatty acid CoA ligase antibody; Long-chain-fatty-acid--CoA ligase antibody; S27A2_HUMAN antibody; Slc27a2 antibody; Solute carrier family 27 (fatty acid transporter), member 2 antibody; Solute carrier family 27 member 2 antibody; THCA CoA ligase antibody; THCA-CoA ligase antibody; Very long chain acyl CoA synthetase antibody; Very long chain fatty acid CoA ligase antibody; Very long chain fatty acid coenzyme A ligase 1 antibody; very long-chain 1 antibody; Very long-chain acyl-CoA synthetase antibody; Very long-chain-fatty-acid-CoA ligase antibody; VLACS antibody; VLCS antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Very long-chain acyl-CoA synthetase protein (283-620AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake.; Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids. Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol.; Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.

Gene References into Functions

In overweight/obese pregnancies, the increased FATP2 placental expression could contribute to increased fatty acid delivery to the fetus. PMID:27016784
In mice Grassofermata decreased absorption of (13)C-oleate demonstrating its potential as a therapeutic agent. PMID:26284975
Protective effects of breastfeeding are reflected in higher expression levels of SLC27A2, FASN, PPARalpha and INSR in blood cells. PMID:24277691
these data support the conclusion that FATP2 has a dual function in the pathways linking the transport and activation of exogenous fatty acids. PMID:24113382
FATP2a functions in fatty acid transport and activation and provides specificity toward n-3 fatty acids in which the corresponding n-3 acyl-CoAs are preferentially trafficked into acyl-CoA pools destined for phosphatidylinositol incorporation PMID:21768100

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Peripheral membrane protein. Cell membrane; Multi-pass membrane protein. Microsome.

Protein Families

ATP-dependent AMP-binding enzyme family

Tissue Specificity

Expressed in liver, kidney, placenta and pancreas.

Database Links

HGNC: 10996

UNIGENE: Hs.11729

KEGG: hsa:11001

STRING: 9606.ENSP00000267842

OMIM: 603247

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