NMT1 Antibody

Code: CSB-PA015900LA01HU

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

P30419

Target Names

NMT1

Alternative Names

Alternative, short form NMT S antibody; EC 2.3.1.97 antibody; Glycylpeptide N tetradecanoyltransferase 1 antibody; Glycylpeptide N-tetradecanoyltransferase 1 antibody; Long form, NMT L antibody; Myristoyl CoA:protein N myristoyltransferase 1 antibody; Myristoyl-CoA:protein N-myristoyltransferase 1 antibody; N myristoyltransferase 1 antibody; NMT 1 antibody; NMT antibody; nmt1 antibody; NMT1_HUMAN antibody; Peptide N myristoyltransferase 1 antibody; Peptide N-myristoyltransferase 1 antibody; Type I N myristoyltransferase antibody; Type I N-myristoyltransferase antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glycylpeptide N-tetradecanoyltransferase 1 protein (1-158AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

IHC image of CSB-PA015900LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Target Background

Function(From Uniprot)

Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.

Gene References into Functions

Genetic and pharmacologic evidence that inhibiting the N-myristoyltransferase NMT1 suppresses cell-cycle progression, proliferation, and malignant growth of prostate cancer cells. PMID:29038344
These observations point at a previously unrecognized contribution of calnexin to the retention of NMT1 at the ER membrane. PMID:26603938
findings suggest that both NMT1 and hnRNP A2/B1 take part in the regulation of HIV-1 RNA expression through their mutual opposite effects on the viral RNA expression in HIV-1-producing cells PMID:26074144
we propose a model of the Nef:NMT complex in which only the myristoyl moiety holds the two proteins together in complex and speculate that perhaps NMT chaperones Nef to the membrane and thereby protects the myristic acid group from the cytosol PMID:21449607
In this study, we found decreases in the mRNA levels of human NMT isoforms and the NMT activities in the course of HIV-1 infection in the human T-cell line PMID:12220649
role of HSC70 in the regulation of NMT PMID:15156568
NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation PMID:16123142
Elevated N-myristoyltransferase activity is associated with oral squamous cell carcinoma PMID:17549352
N-myristoyltransferase may have a role in progression of colonic neoplasms PMID:18021392
Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence. PMID:18089753
These results strongly suggest that HIV-1 production is specifically associated with hNMT1, particularly hNMT1(L), but not with hNMT2 in vivo, contributing to the understanding of a step in HIV-1 replication. PMID:18248763