LRPAP1 Antibody

Code: CSB-PA156966

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

P30533

Target Names

LRPAP1

Alternative Names

39 kDa receptor-associated protein antibody; A2MRAP antibody; A2RAP antibody; Alpha 2 macroglobulin receptor associated protein antibody; Alpha 2 MRAP antibody; Alpha-2-macroglobulin receptor-associated protein antibody; Alpha-2-MRAP antibody; AMRP_HUMAN antibody; HBP44 antibody; Lipoprotein receptor associated protein antibody; Low density lipoprotein receptor related protein associated protein 1 antibody; Low density lipoprotein receptor-related protein-associated protein 1 antibody; Low density lipoprotein related protein associated protein 1 alpha 2 macroglobulin receptor associated protein antibody; Low density lipoprotein related protein associated protein 1 antibody; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1) antibody; Lrpap1 antibody; MGC138272 antibody; MRAP antibody; MYP23 antibody; RAP antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human LRPAP1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA156966(LRPAP1 Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, Human fetal kidney tissue, Primary antibody: CSB-PA156966(LRPAP1 Antibody) at dilution 1/1600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

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Target Background

Function(From Uniprot)

Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway.

Gene References into Functions

The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene. PMID:26271838
The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3's binding to GTP was not. PMID:25159528
The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE epsilon4 allelic variant. PMID:24504617
RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells. PMID:23894629
Mutations in LRPAP1 are associated with severe myopia in humans. PMID:23830514
LRP1-C/T, A2M-Ile/Val and APOE-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD. PMID:20637261
Findings reveal that RAP is a novel Abeta-binding protein that promotes cellular internalization of Abeta. PMID:19826010
Adenoviral-mediated expression of human receptor-asociated protein RAP in a murine model of von Willebrand disease results in a continuous rise in FVIII over 6 days. PMID:11992244
RAP is organized into three domains located in the first third (1D), middle third (2D), and last third (3D) of the protein; all three domains adopt stable tertiary structure as isolated domains and are monomers. PMID:14674767
NMR structure of domain 1 of receptor-associated protein PMID:15213425
An insertion allele is found to be associated with gallstone disease. PMID:16704534
RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo PMID:17123336
analysis of the relationship between ACE and LRPAP1 gene polymorphisms and age in an Italian population PMID:17536759
Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. PMID:17913606
Low-density lipoprotein receptor-related protein associated protein (LRPAP1) insertion/deletion polymorphism is associated with gallstone disease and gallbladder carcinoma PMID:17987404
LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells. PMID:18055545
alterations of the RAP gene are not a common cause of hypothyroidism PMID:18075286
Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias. PMID:18721259

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Subcellular Location

Rough endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment lumen. Golgi apparatus, cis-Golgi network. Golgi apparatus lumen. Endosome lumen. Cell surface.

Protein Families

Alpha-2-MRAP family

Database Links

HGNC: 6701

UNIGENE: Hs.40966

KEGG: hsa:4043

STRING: 9606.ENSP00000421922

OMIM: 104225

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