CTSH Antibody

Code: CSB-PA006191LA01HU

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US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

P09668

Target Names

CTSH

Alternative Names

ACC 4 antibody; ACC 5 antibody; ACC4 antibody; ACC5 antibody; aleurain antibody; CATH_HUMAN antibody; cathepsin B3 antibody; cathepsin BA antibody; Cathepsin H heavy chain antibody; Cathepsin H light chain antibody; Cathepsin H mini chain antibody; CPSB antibody; CTSH antibody; minichain antibody; N benzoylarginine beta naphthylamide hydrolase antibody; N-benzoylarginine-beta-naphthylamide hydrolase antibody; pro cathepsin H antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pro-cathepsin H protein (116-219AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: SH-SY5Y whole cell lysate, K562 whole cell lysate
All lanes: CTSH antibody at 2.7µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA006191LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006191LA01HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Important for the overall degradation of proteins in lysosomes.

Gene References into Functions

the up-regulation of MMP genes is mediated through degradation of class IIa histone deacetylases (HDACs) by certain cysteine cathepsins (Cts). PMID:28157489
Especially, rs3825932 in CTSH has integrative functional evidence supporting the association with type 1 diabetes mellitus. PMID:26429317
p41 fragment is also shown to reduce the secretion of interleukin-12 (IL-12/p70) during the subsequent maturation of treated dendritic cells. PMID:26960148
In conclusion, CTSH/rs3825932 and ERBB3/rs2292239 SNPs were associated with reduced risk of progression to proliferative diabetic retinopathy and two-step progression of diabetic retinopathy on the ETDRS scale accordingly. PMID:26245339
mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2. PMID:25525168
The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D PMID:24982147
CtsH-mediated processing of talin might promote cancer cell progression by affecting integrin alphaVbeta3 activation and adhesion strength PMID:23204516
The processing of procathepsin H is an autocatalytic, multistep process proceeding from an inactive 41kDa pro-form, through a 30kDa intermediate form, to the 28kDa mature form. PMID:22704610
CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression. PMID:21217776
These data indicate that cathepsins B, L and S may act as cell-death mediators in in monocytic cells infected with ICP4 and Us3 deletion mutant herpes simplex virus type 1. PMID:20881085
involvement in processing of hydrophobic surfactant-associated protein C in type II pneumocytes PMID:12034564
Cathepsin H could contribute to the transformation of LDL to an atherogenic moiety; the process might involve a self-sustaining amplifying circle. PMID:12615673
kinetic data on substrates hydrolysis and enzyme inhibition show the role of the mini-chain as a framework for transition state stabilization of free alpha-amino groups of substrates and as a structural barrier for endopeptidase-like substrate cleavage. PMID:14515996
AKR1B1 and CTSH may be good markers for prediction of sensitivity to certain drugs PMID:14662023
cathepsin H is involved in maturation of the biologically active surfactant associated protein B PMID:14766755
cathepsin H has a role in progression of colorectal cancer that is distinct from that of cathepsins B and L PMID:15646835
A general defect in napsin A or cathepsin H expression or activity was not the specific cause for abnormal surfactant accumulation in juvenile pulmonary alveolar proteinosis PMID:18216060
In contrast to cathepsin S, cathepsin H values did not correlate with markers of inflammation, indicating a specific role for cathepsin H in the pleural host response. PMID:19404922