ATG4C Antibody

Code: CSB-PA836199ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q96DT6

Target Names

ATG4C

Alternative Names

APG4 autophagy 4 homolog C (S. cerevisiae) antibody; APG4 autophagy 4 homolog C antibody; APG4 C antibody; APG4-C antibody; APG4C antibody; ATG 4C antibody; ATG4 autophagy related 4 homolog C (S. cerevisiae) antibody; ATG4 autophagy related 4 homolog C antibody; Atg4c antibody; ATG4C_HUMAN antibody; AUT (S. cerevisiae) like 1; cysteine endopeptidase antibody; AUT like 1; cysteine endopeptidase (S. cerevisiae) antibody; AUT like 1; cysteine endopeptidase antibody; AUT like 3 cysteine endopeptidase antibody; AUT-like 3 cysteine endopeptidase antibody; AUTL1 antibody; AUTL3 antibody; Autophagin 3 antibody; Autophagin-3 antibody; Autophagy related 4C cysteine peptidase antibody; Autophagy related cysteine endopeptidase 3 antibody; Autophagy related protein 4 homolog C antibody; Autophagy-related cysteine endopeptidase 3 antibody; Autophagy-related protein 4 homolog C antibody; Cysteine protease ATG4C antibody; EC 3.4.22 antibody; FLJ14867 antibody; OTTHUMP00000010715 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Cysteine protease ATG4C protein (259-458AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: ATG4C antibody at 9μg/ml
Lane 1: Mouse lung tissue
Lane 2: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA836199ESR2HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Gene References into Functions

association between SNPs and Kashin-Beck disease PMID:27742532
We demonstrate that, in breast cancer cells, ATM and ATG4C are essential drivers of mammosphere formation, suggesting that their targeting may improve current approaches to eradicate breast cancer cells with a stem-like phenotype. PMID:28423511
miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1. PMID:22248718

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Subcellular Location

Cytoplasm.

Protein Families

Peptidase C54 family

Database Links

HGNC: 16040

UNIGENE: Hs.7353

KEGG: hsa:84938

STRING: 9606.ENSP00000322159

OMIM: 611339

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