Rat transforming growth factor α,TGF-α ELISA Kit

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Code: CSB-E07289r

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Size:

96T,5×96T,10×96T

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Quantity:

Sample Types: serum, plasma, tissue homogenates

Detect Range: 7.8 pg/ml-500pg/ml

Sensitivity: 1.95 pg/ml

Trial Size:

24T ELISA Kit Trial Size (Only USD$150/ kit)
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Product Details
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Target Background

Product Details

Alternative Names

Tgfa ELISA Kit; Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ELISA Kit; TGF-alpha ELISA Kit; EGF-like TGF ELISA Kit; ETGF ELISA Kit; TGF type 1)] ELISA Kit

Abbreviation

TGFA

Uniprot NO.

P01134

Species

Rattus norvegicus (Rat)

Sample Type

serum, plasma, tissue homogenates

Detection Range

7.8 pg/ml-500pg/ml

Sensitivity

1.95 pg/ml

Assay Time

1-5h

Sample Loading Volume

50-100ul

Detection Wavelength

450 nm

Research Area

Signal Transduction

Assay Principle

quantitative
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Measurement

Sandwich

Storage

Store at 2-8°C. Please refer to protocol.

Shelf Life

6 months

Lead Time

3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Troubleshooting and FAQs

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ELISA Data Analysis

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Description

The Rat Transforming Growth Factor α (TGF-α) ELISA Kit is designed for the accurate and reliable detection of transforming growth factor alpha (TGF-α) in serum, plasma, and tissue homogenates of Rattus norvegicus (rat) samples.

The assay is based on the quantitative sandwich method and has a detection range of 7.8 pg/ml to 500 pg/ml, with a sensitivity of 1.95 pg/ml. With a quick assay time of 1-5 hours and a sample volume of 50-100ul, this kit provides an efficient and time-saving solution for researchers in the signal transduction field.

The detection wavelength for this kit is 450 nm, providing high sensitivity and specificity for the measurement of TGF-α in rat samples. The Rat Transforming Growth Factor α, TGF-α ELISA Kit is based on a sandwich assay principle that provides high specificity and accuracy for the detection of this protein.

The Rat Transforming Growth Factor α (TGF-α) ELISA Kit is ideal for researchers studying signal transduction,cell migration, growth, and differentiation. Whether you are investigating the role of TGF-α in the development of cancer or its potential as a therapeutic target, this kit offers a reliable and accurate means of quantifying TGF-α levels in your samples.

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Target Background

Function(From Uniprot)

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Gene References into Functions

5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID:26804134
Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID:24595367
results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID:12021046
A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID:12029622
TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID:12771152
TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID:14656002
TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID:15353178
study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID:17968906
mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID:19237431
TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID:11487584

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Subcellular Location

[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.

Database Links

UNIGENE: Rn.9952

KEGG: rno:24827

STRING: 10116.ENSRNOP00000054248

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